Human Ancestors Got Herpes from Chimps' Ancestors

A herpes virus that infects humans originated in chimpanzees before it jumped into our early human ancestors, according to a new study.

Researchers found that herpes simplex virus 1 (HSV-1) infected hominids before their evolutionary split from chimpanzees 6 million years ago, whereas herpes simplex 2 (HSV-2) was transferred from ancient chimpanzees to human ancestors such as Homo erectus about 1.6 million years ago, long before the rise of early modern humans about 200,000 years ago.

"Before we were human, there was still cross-species transmission into our evolutionary lineage," study author Joel O. Wertheim, assistant research scientist at the University of Californai, San Diego AntiViral Research Center, told Live Science.
About two-thirds of the human population is infected with at least one kind of herpes simplex virus, according to the researchers. HSV-1 commonly manifests itself as cold sores on the mouth or lips, whereas HSV-2 can cause blisters on the genitals.

Humans are also the only primate species that can be infected by more than one herpes simplex virus, the researchers said. [10 Deadly Diseases That Hopped Across Species]

In the study, the researchers compared human herpes viruses with those of other primates. They used advanced models of molecular evolution to estimate when and how exactly the viruses had diverged from each other, and how they were introduced into humans.

According to a previous hypothesis, HSV-1 was thought to have been introduced to humans "potentially from another ape species, like orangutans," Wertheim said. And the split between HSV-2 and its chimpanzee counterpart was thought to have coincided with the split between humans and chimpanzees.

In contrast, the new study suggests that HSV-2 is the result of cross-species transmission to humans from ancestors of modern chimpanzees, and that HSV-1 is the result of a split between the human and chimpanzee viruses, he said.

Now, both humans and chimpanzees have their own version of the HSV-1 virus, he said.

The results may help scientists better understand the mechanism of species-to-species transmission, which still happens, the study authors said. For instance, people today often get infected with a macaque simplex virus, which can result in severe illness, the researchers wrote in the study. But human-to-human transmission of this virus is extremely rare, they wrote.

"Understanding how and when we acquired viruses that currently infect us can give us perspective on future, potential cross-species transmission events that would lead to the introduction of new human viruses," Wertheim said

"Knowing that some of our viruses are much older and some of the are more recent is important for that perspective," he said.

For instance, cross-species transmissions of some viruses, such as the one causes Severe Accute respiratory syndrome (SARS), are very recent, whereas other viruses such as HIV are slightly older, about 100 years, Wertheim said.

The study was published in the June 10 online issue of Molecular Biology and Evolution.

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