Fasting triggers stem cell regeneration of damaged, old immune system

by UN.i1-PHI on August 16th, 2014

Fasting triggers stem cell regeneration of damaged, old immune system

Protection from chemotherapy immunosuppression indicates effect could be conserved in humans

In the first evidence of a natural intervention triggering stem cell-based regeneration of an organ or system, a study in the June 5 issue of the Cell Stem Cell shows that cycles of prolonged fasting not only protect against immune system damage — a major side effect of chemotherapy — but also induce immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal.

In both mice and a Phase 1 human clinical trial involving patients receiving chemotherapy, long periods of not eating significantly lowered white blood cell counts. In mice, fasting cycles then “flipped a regenerative switch,” changing the signaling pathways for hematopoietic stem cells, which are responsible for the generation of blood and immune systems, the research showed.

We could not predict that prolonged fasting would have such a remarkable effect in promoting stem cell-based regeneration of the hematopoietic system.

Valter Longo

The study has major implications for healthier aging, in which immune system decline contributes to increased susceptibility to disease as people age. By outlining how prolonged fasting cycles — periods of no food for two to four days at a time over the course of six months — kill older and damaged immune cells and generate new ones, the research also has implications for chemotherapy tolerance and for those with a wide range of immune system deficiencies, including autoimmunity disorders.

“We could not predict that prolonged fasting would have such a remarkable effect in promoting stem cell-based regeneration of the hematopoietic system,” said corresponding author Valter Longo, Edna M. Jones Professor of Gerontology and the Biological Sciences at the USC Davis School of Gerontology and director of the USC Longevity Institute. Longo has a joint appointment at the USC Dornsife College of Letters, Arts and Sciences.

“When you starve, the system tries to save energy, and one of the things it can do to save energy is to recycle a lot of the immune cells that are not needed, especially those that may be damaged,” Longo said. “What we started noticing in both our human work and animal work is that the white blood cell count goes down with prolonged fasting. Then when you re-feed, the blood cells come back. So we started thinking, well, where does it come from?”

Fasting cycles

Prolonged fasting forces the body to use stores of glucose, fat and ketones, but it also breaks down a significant portion of white blood cells. Longo likens the effect to lightening a plane of excess cargo.

During each cycle of fasting, this depletion of white blood cells induces changes that trigger stem cell-based regeneration of new immune system cells. In particular, prolonged fasting reduced the enzyme PKA, an effect previously discovered by the Longo team to extend longevity in simple organisms and which has been linked in other research to the regulation of stem cell self-renewal and pluripotency — that is, the potential for one cell to develop into many different cell types. Prolonged fasting also lowered levels of IGF-1, a growth-factor hormone that Longo and others have linked to aging, tumor progression and cancer risk.

“PKA is the key gene that needs to shut down in order for these stem cells to switch into regenerative mode. It gives the OK for stem cells to go ahead and begin proliferating and rebuild the entire system,” explained Longo, noting the potential of clinical applications that mimic the effects of prolonged fasting to rejuvenate the immune system. “And the good news is that the body got rid of the parts of the system that might be damaged or old, the inefficient parts, during the fasting. Now, if you start with a system heavily damaged by chemotherapy or aging, fasting cycles can generate, literally, a new immune system.”

Prolonged fasting also protected against toxicity in a pilot clinical trial in which a small group of patients fasted for a 72-hour period prior to chemotherapy, extending Longo’s influential past research.

“While chemotherapy saves lives, it causes significant collateral damage to the immune system. The results of this study suggest that fasting may mitigate some of the harmful effects of chemotherapy,” said co-author Tanya Dorff, assistant professor of clinical medicine at the USC Norris Comprehensive Cancer Center and Hospital. “More clinical studies are needed, and any such dietary intervention should be undertaken only under the guidance of a physician.”

“We are investigating the possibility that these effects are applicable to many different systems and organs, not just the immune system,” said Longo, whose lab is in the process of conducting further research on controlled dietary interventions and stem cell regeneration in both animal and clinical studies.

The study was supported by the National Institute of Aging of the National Institutes of Health (grant numbers AG20642, AG025135, P01AG34906). The clinical trial was supported by the V Foundation and the National Cancer Institute of the National Institutes of Health (P30CA014089).

Chia Wei-Cheng of USC Davis was first author of the study. Gregor Adams, Xiaoying Zhou and Ben Lam of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC; Laura Perin and Stefano Da Sacco of the Saban Research Institute at Children’s Hospital Los Angeles; Min Wei of USC Davis; Mario Mirisola of the University of Palermo; Dorff and David Quinn of the Keck School of Medicine of USC; and John Kopchick of Ohio University were co-authors of the study.

picture source:
Immunity is Improved if Fasting is Done for 3 days, Increases WBC Count

 Filed under: Science, fasting, diet, stem cells, immune system


obsrvantlouie: Interesting article

I have been experimenting with fasting and cleaned recently. I have done a SEA SALT cleanse (natural colon cleanse) which worked want to use high quality sea salt (Himalayan, Aztec or pink salt). This is also a great way to balance the body's ph level. I have also done a juice fast recently which worked well also.

A key to fasting is not underestimate it's effects....eps socially your first time fasting, one should plan on being near the couch/bed just incase your energy level is effected to the point of exhaustion. There are many pre qualifying conditions and circumstances to consider before attempting a fast but the benefits can be wonderful.

Even a mini fast (12 hours) does the body wonders.

Lastly, I remind people often who are allopathic medicine fans that 75% of doctors polled would not take chemotherapy if they became diagnosed with cancer.

More times than not the body can heal itself if the mind let's it....add in the correct homeopathic remedies, exercise and rest and boom! Healthy body.

UN.i1-PHI: thats good to hear from ya OL

That youve been doing some fasting and salt cleansing
I appreciate your input esp saying not to undereatimate the effects as there are many benevolant effects that come along and you warned to stay in a safe environment esp the first time but i just could continue doing regular daily things with ease
Ive fasted for 3 days now and yesterday i even did without drinking water so soon im gonna drink some water and eat some nice fruits of life, well from the store but this fasting for 3 days triggers stem cell regeneration for many systems (aside from the immune system) still to be researched tough ull have to fast a few days more often in that month to increase effect and completion
so now i fasted i guess i got rid of a lot of damaged cells and its time to regenerate healthy cells and immune system by eating healthy food i still have like mangos, peaches, grapes, pine apple, melons, lemons&limes, bananas , grapefruits etc ,
Dunno whats up for dinner i better dont cook vegs but what about rice or patatoes with steamed or even better raw vegs
I stopped eating bread too because sourdough also contains kinds of yeasts and its much better to eat sprouting grains like ezekiel bread but i dont have a dehydrator to make dry bread from the dough so no mo bread for me tough i also finally stopped with tabacco in my j'smoke
Almost forgot to say that ppl also should not overetstimte the difficulty in fasting , yes its also a mental thing but it aint that hard to resist temptation as i have no problems or difficultiez at all and im doing just fine and aint even that hungry all this time as the hungry feeling disappears pretty quickly anyway
Btw when you said juice do you really extract the juices or do you blend it all with pulp (wich is much more healthy as it wont force spike up your blood shugar levels ( wich then dramatically reduces atleast thats what happens when ya eat white flour) and dicgests\utilizes the combination of substances properly and more smoothly (as the fruit is meant to be eaten with its inner membranes (and for many even the skin) you can better mash em up into pulp in a smoothie) and if ya want a quick healthy energy boost bananas are there for you right
Well this much for talking about eating food for now imma get started with some mango too delicious to make em wait any longer tough ill also make some alkalizing lemonade with honey to drink today its time to regenerate

obsrvantlouie: Very nice

Regards to the bread...I have started to eliminate bread in substitute of granola and oatmeal, seems to be working nicely for me. Funny thing is that it's very difficult to find non GMO and or organic bread. Many breads contain HFC (high fructose cornsyrup) and wheat gluten. Even though I love bread - I do notice I function better and especially feel better when I don't eat it.

Regards to the juice fast....I purchase Lakewood brand organic fruit juices; I'm sure it's cheaper and healthier to actually juice fresh fruits and veggies rather than buying then but sometimes "time is money".

I have to suggest a book well worth the money....only $25 dollars. "Natural healing, wisdom and know how" authored Amy Rost.

Some superfoods to mention that are staples of my nutrition...

Turmeric - massive health benefits
Garlic - good for digestive system and cleanses stomach.
Bee pollen - I just got on to this 6 months ago- claims to prevent allergies if taken 6 weeks in advance and I must say it works.
Honey - great for immune system
Papaya - loaded with vitamin C (I drink juice but the fruit is good as well).
Spinach - Popeye wasn't lying...miss you robin Williams.

Eggs - lot of debate here but I have determined the yolks are far more beneficial than the scare tactic of causing high cholesterol.
Fresh nuts - almonds..yum, good for the heart.
Turnips and red beets - powerful foods for cardiovascular and nervous system.

Fresh fruits and green veggies.

I indulge here and there on dark chocolate and I still love vanilla yogurt!

Probably a good move to remove the Tobacco from mj....Notice a difference?

UN.i1-PHI: The FDA Conspiracy & Bleached Flour, Austin Nutrition

The FDA Conspiracy & Bleached Flour, Austin Nutrition

thanks very much again for ur replies, very nice and useful/informative
i dont eat animal substances and avoid them, tough i recently got to hear that carbonell olive oil has some fish oil in it and coolbest also some fish gelatine stuff to carry the vitamins or something wich i just happened to consume some of quite recently tough i dont drink juices from the packets anymore for quite some time i think with a few exceptions, one ofwich i just mentioned shows that it was regretfull to me
so i also dont eat egg or vanilla yoghurt, wich is also full of (cultivated) micro organisms/ bacteries, i avoid yeast, well atleast commercial cultivated yeast, so i went to eat sourdough but theres also yeasts in but they are natural and not artificially cultivated in 'sterile enviorment' to get the 'one' type they need/use, so these natural bacteries/yeasts are naturally there in the air, water etc, and atleast they're naturally cultivated by the fermentation when making sourdough wich is better than bread with commercial yeast, however i'm not so sure if i want to consume a whole cultivated culture of microorganisms so but they're natural, but theyre in so huge amounts that i think its not natural to consume but maybe doesnt matter that much i'm doubting if i should continue eating sourdough bread, best is ofcourse if you make it yourself and then you keep a piece of the dough to create the next over time and becomes much more cheaper to make btw, and the ezekiel bread (just heard of it yesterday) has (commercial) yeast in it but it is an example of bread that is based on the sprouting grains wich is the most healthy part the sprouts are missing from the flower and when its processed not properly it loses all life power/nutrients by denaturating/breaking te enzymes due to high temperatures from mashing seeds
however a huge problem is the flour especially if its bleached(not in EU) and lifeless, and mixed with artificial white well watch the vid if you want it explained extensively, it actually causes a lot of diseases as obesitas in long term and also in short term the flour spike up your blood shugar levels and quickly get depleted again etc

Give us this day our daily bread ..?
( translated with google into english for ya)

UN.i1-PHI: ugh blehh bread...

OL you told how much better you felt without eating bread, well i was feeling irie too after fasting but now i anyway ate some (sourdough) bread i used to like before i was fasting and now i cant even finish it because its feeling too bad for my stomach i can feel it is not good for me and i regret eating it cause i actually wanted to stop with that so i guess now i'll really stop with it as now i can feel how bad it actually is...
my stomach felt weirder than eating the devil's egg (shroom-bulb) after some pineapple yesterday lol
and about the joints i do notice a diffrence that i dont feel the need to smoke tough i still blazed 2 hasj joints as the last ones i'd smoke with tobacco tough in the end it wasnt really worth it i better stick with the pure peace pipe
the experiences are pretty different than before fasting and tough it wasnt good for me atleast it made me clearly feel i want (or rather need) to stop fo it real
i'll be fasting again sometime soon for more cleansing and regenerating

so i guess after fasting you can sense much better what is good for you and what is not, and can help motivate you to change your mind&diet on certain things you used to ingest/indulge regularly that felt normal because you made it 'normal' so your body gets used to it and kinda ignores the bad feeling of it cause its conditioned to accept it and deal with it, in both physical and mental aspects...

Tarheel: Good post, UNI.

I agree that fasting is 1 way to shock awake certain powers/abilities.
Eating right, exercising and meditating (grouped) works ...there are many ways.

Liked seeing the advice from that health guru-OL. (lmao)

UN.i1-PHI: Meditation unleashes molecular changes in the body

Meditation unleashes molecular changes in the body

There is increasing evidence that meditation also has a beneficial effect on the body and physical health. Scientists investigate how that effect with meditation can be achieved. A study by researchers from the American state of Wisconsin, Spain and France reported the first evidence of specific molecular changes in the body, after a period of mindfulness meditation.

We investigated the physical effects were noticeable after a day of intensive mindfulness by a group of experienced meditators and a group of untrained people. After eight hours of mindfulness meditators showed a variety of genetic and molecular differences, including altered levels of gene regulatory systems and inflammatory genes. These differences are linked to a faster physical recovery after a stressful situation.

Previous studies have documented the beneficial effects of mindfulness on inflammatory diseases already shown. Training based on mindfulness meditation are endorsed by the American Heart Association as a preventive treatment.

Meditation found to relate to genes that are responsible for inflammation. Have a regulating effect This effect was also associated with less stress and have trouble speaking in public or in front of an audience or a camera.

At the beginning of the study, there was no difference between the investigated genes from the two groups of participants. The effects were observed only at the meditators. According to researchers calmness of mind has a beneficial effect on the body.

Scientists have laid the foundation for future studies on the treatment of chronic inflammatory diseases with meditation. The study is published in the journal Psychoneuroendocrinology .

[ UW-Madison ]
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obsrvantlouie: A lot of proper

Meditation has to do with proper breathing.....'yellow emperors calssic' is enjoyable to read and offers much perspective.

So many ailments can be cured with yoga.

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